Threshold mechanisms in acetylcholine pathway insecticides and environmental safety

Overview Previously we looked at some of the basic principles of nervous system function and how chemicals from several pesticide classes disrupt normal function.  This time we will look in detail about what we can expect for a dose-response characterization of acetylcholine pathway insecticides based upon their mode of action and properties of the nervous system. [...]

EPA’s Proposed Imidacloprid Exposure Limitations are Not Strong Enough

Our comment letter to EPA follows below.   OPP Docket Environmental Protection Agency Docket Center (EPA/DC), (28221T) 1200 Pennsylvania Ave. NW. Washington, DC 20460-0001   Re: Pollinator Ecological Risk Assessments: Imidacloprid Registration Review EPA-HQ-OPP-2008-0844   To whom it may concern, We would like to offer some comments on the regulatory endpoints that are proposed in [...]

Blog post gets Published!

What started out as a bit of curiosity about the time-dependent toxicity of insecticides led to a blog piece I did a little over a year ago titled Time-dependent Toxicity of Imidacloprid in Bees and Ants.  I thought my results were interesting enough to get a comment from other scientists that were looking at the time-dependent [...]

The Mechanisms of Neuro-toxic Pesticides

Agricultural pesticides have become part of the chemical landscape that we all  live in.  To be able to make intelligent decision about the use and regulation of these chemicals, it's important to understand how they work.  Almost all modern pesticides are chemicals that interfere in some way with the nervous system. The characteristics of the [...]